Related Experiment Video
Updated: May 10, 2026
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Testosterone supplementation's effects on age-related bladder remodeling - experimental study in rats
Charles Alberto Villacorta de Barros1, Fábio Lorenzetti, Valdemar Ortiz
1Federal University of São Paulo, Rua dos Otonis, São Paulo, Brazil. charles_villacorta@hotmail.com
Summary
Testosterone replacement therapy reduced bladder wall fibrosis in aging rats. This finding suggests potential benefits for age-related detrusor muscle changes.
Area of Science:
- Urology
- Aging Research
- Endocrinology
Background:
- Aging is associated with detrusor muscle fibrosis.
- Fibrosis can impair bladder function.
- Testosterone levels decline with age.
Purpose of the Study:
- To investigate the impact of testosterone replacement on detrusor muscle fibrosis in aging rats.
- To assess if testosterone can mitigate age-related fibrotic changes.
Main Methods:
- 15 senile Wistar rats were divided into testosterone and control groups.
- Testosterone undecanoate was administered monthly for eight weeks.
- Stereological evaluation quantified collagen fiber density in bladders.
Main Results:
- Testosterone group had significantly higher serum testosterone levels (3.2 ng/ml) than controls (0.64 ng/ml).
- Collagen fiber density was significantly lower in the testosterone group (37.02%) compared to the control group (56%).
Conclusions:
- Testosterone replacement therapy effectively reduced bladder wall fibrosis in senile rats.
- This suggests a potential therapeutic role for testosterone in managing age-related bladder fibrosis.
