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Updated: May 10, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
[A quantitative investigation of E2F1-regulated cell cycle compensation mechanism]
1Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. liuwenyin@126.com
Objective:
To explore the core mechanism of cell cycle compensation using a mathematical model.
Methods:
A set of ordinary differential equations were used to describe the interactions between the core cell cycle molecules. Continuous and cyclic changes of the concentrations of these molecules were computed to capture the discrete events of molecular interactions.
Results:
The calculated molecule concentrations and captured signaling events agreed with the experimental results.
Conclusion:
E2F transcription factor 1 is the pivotal element linking the positive and negative feedbacks and regulating G1/S and G2/M phase compensation.
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