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Translational research in pediatric extracorporeal life support systems and cardiopulmonary bypass procedures: 2011
Feng Qiu1, Jonathan Talor, Jeffrey Zahn
1Penn State Hershey Pediatric Cardiovascular Research Center, Departments of Pediatrics, Surgery, Bioengineering, Public Health Sciences, and Comparative Medicine, Penn State Hershey College of Medicine, Penn State Hershey Children's Hospital, Hershey, PA, USA.
Insights
Penn State Hershey
Area of Science:
- Pediatric Cardiovascular Research
- Translational Medicine
- Biomedical Engineering
Background:
- Established a pediatric cardiovascular research center over 6 years.
- Multidisciplinary team focused on improving outcomes for pediatric cardiac surgery patients.
- Utilized cardiopulmonary bypass (CPB) and extracorporeal life support (ECLS) technologies.
Purpose of the Study:
- Summarize translational research at Penn State Hershey.
- Share latest results on pediatric CPB and ECLS device selection.
- Inform other centers on optimal device choices for pediatric patients.
Main Methods:
- Conducted in vitro and in vivo translational research.
- Evaluated various commercially available pediatric CPB and ECLS devices.
- Utilized research findings to select clinical components.
Main Results:
- All components used in clinical settings are based on translational research findings.
- Optimized device selection for pediatric patients undergoing cardiac surgery.
- Established a data-driven approach to pediatric cardiovascular support.
Conclusions:
- Translational research is crucial for selecting optimal pediatric CPB and ECLS devices.
- Penn State Hershey's research has directly informed clinical practice.
- Sharing research findings can advance care for children requiring cardiac support.
Abstract:
Over the past 6 years at Penn State Hershey, we have established the pediatric cardiovascular research center with a multidisciplinary research team with the goal to improve the outcomes for children undergoing cardiac surgery with cardiopulmonary bypass (CPB) and extracorporeal life support (ECLS). Due to the variety of commercially available pediatric CPB and ECLS devices, both in vitro and in vivo translational research have been conducted to achieve the optimal choice for our patients. By now, every component being used in our clinical settings in Penn State Hershey has been selected based on the results of our translational research. The objective of this review is to summarize our translational research in Penn State Hershey Pediatric Cardiovascular Research Center and to share the latest results with all the interested centers.
