Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesterol absorption by the gall bladder.

P E Ross1, A N Butt, C Gallacher

  • 1Department of Medicine, Ninewells Hospital Medical School, Dundee.

Journal of Clinical Pathology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dissolution and microbial degradation of mobile aromatic hydrocarbons from a Pintsch gas tar DNAPL source zone.

The Science of the total environment·2020
Same author

Circulating nucleic acids in the assessment of endogenous growth hormone production.

Annals of the New York Academy of Sciences·2008
Same author

Stability of beta-actin mRNA in plasma.

Annals of the New York Academy of Sciences·2008
Same author

Normalization of circulating nucleic acid results.

Annals of the New York Academy of Sciences·2008
Same author

Retina-specific mRNA in the assessment of diabetic retinopathy.

Annals of the New York Academy of Sciences·2008
Same author

Measurement of circulating neuron-specific enolase mRNA in diabetes mellitus.

Annals of the New York Academy of Sciences·2008
Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026
Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026
Same journal

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same journal

MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

Journal of clinical pathology·2026
Same journal

Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

Journal of clinical pathology·2026
Same journal

Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

Journal of clinical pathology·2026
See all related articles

Gallbladder absorption of cholesterol and dextran differs, with cholesterol uptake influenced by concentration and temperature, while dextran absorption is via endocytosis. Bile salt composition affects permeability to both molecule types.

Area of Science:

  • Gastroenterology
  • Biliary Physiology
  • Molecular Transport

Background:

  • Gallbladder function is crucial for bile salt and lipid homeostasis.
  • Understanding the mechanisms of cholesterol and dextran absorption is key to biliary disease research.

Purpose of the Study:

  • To investigate factors influencing cholesterol and dextran absorption by the gallbladder.
  • To elucidate the distinct uptake mechanisms for cholesterol and dextran.
  • To examine the impact of bile composition on gallbladder permeability.

Main Methods:

  • Utilized both model and real bile preparations for comparative analysis.
  • Assessed absorption rates of cholesterol and dextran under varying conditions (cholesterol concentration, temperature, bile salt composition).

Related Experiment Videos

  • Differentiated uptake mechanisms based on experimental observations.

    • Main Results:

    • Cholesterol absorption correlated with concentration in real bile but saturated in model bile.
    • Reduced temperature decreased cholesterol absorption but not dextran absorption.
    • Cholesterol uptake followed passive diffusion, while dextran uptake occurred via fluid-phase endocytosis.
    • Cholesterol uptake was lowest in cholate bile, with highest serosal secretion.
    • Dextran uptake was also lowest in cholate bile, with highest serosal secretion.

    Conclusions:

    • Increased dihydroxy bile salts in bile enhance gallbladder permeability to both hydrophobic (cholesterol) and hydrophilic (dextran) molecules.
    • Altered bile salt composition may contribute to lipid accumulation in the gallbladder mucosa, potentially leading to cholesterolosis.