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Updated: May 10, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
A rare case of prostatic malignancy
T A Kishore1, Abijit Shetty, B K Tharun
1Department of Urology, Medical Trust Hospital, Cochin, Kerala, India. kishoreta@yahoo.com
Indian Journal of Medical Sciences
|June 29, 2013
Summary
This case study highlights a rare instance of advanced prostate cancer with metaplasia, presenting challenges in urinary retention management. Despite initial treatments, the cancer recurred and metastasized, necessitating palliative care.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- A 70-year-old male with a history of prostate adenocarcinoma with metaplasia experienced refractory urinary retention.
- The patient had previously undergone transurethral resection of prostate (TURP) and bilateral orchidectomy.
Observation:
- Following initial TURP and orchidectomy, the patient presented again with urinary retention and similar histopathology findings.
- A subsequent bone scan revealed solitary metastasis to the second rib, with MRI and CT confirming tumor regrowth.
Findings:
- The resected prostatic tissue consistently showed differentiated adenocarcinoma with cartilaginous and osseous metaplasia.
- Despite palliative radiation alleviating urinary symptoms, the patient opted for conservative management over radical cystoprostatectomy.
Implications:
- This case underscores the aggressive nature of prostate adenocarcinoma with metaplasia and its potential for metastasis.
- It emphasizes the importance of vigilant monitoring and tailored management strategies for recurrent or metastatic prostate cancer, even in palliative settings.
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