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Persistent middle cerebral artery occlusion associated with lower body temperature on admission

Christopher Elnan Kvistad1, Halvor Øygarden, Lars Thomassen

  • 1Department of Neurology, Haukeland University Hospital, Bergen, Norway. echr@helse-bergen.no

Vascular Health and Risk Management
|June 29, 2013
PubMed
Abstract

Insights

Low body temperature may hinder clot lysis in acute ischemic stroke patients. This study found lower admission temperatures were linked to persistent middle cerebral artery occlusion, suggesting a detrimental effect on recanalization.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Stroke Medicine

Background:

  • Hypothermia is considered neuroprotective in ischemic stroke.
  • However, low body temperature may impede clot lysis and recanalization.
  • This study investigated the association between low body temperature and recanalization in acute ischemic stroke.

Purpose of the Study:

  • To determine if low body temperature is associated with persistent proximal middle cerebral artery (MCA) occlusion.
  • To explore the potential detrimental effect of hypothermia on recanalization in acute ischemic stroke.

Main Methods:

  • Prospective registration of acute ischemic stroke patients (February 2006 - August 2012).
  • Computed tomography (CT) angiography performed within 6 hours of stroke onset.
  • Comparison of patients with proximal MCA occlusion versus total anterior circulation infarct (TACI) without MCA occlusion.

Main Results:

  • 384 patients underwent CT angiography; 79 had proximal MCA occlusion.
  • Median admission body temperature was lower in patients with MCA occlusion (36.3°C vs. 36.7°C).
  • Body temperature <36.5°C independently associated with persistent MCA occlusion (OR 3.7, P=0.007).

Conclusions:

  • Low admission body temperature is associated with persistent proximal MCA occlusion.
  • These findings suggest hypothermia may negatively impact clot lysis and recanalization in acute ischemic stroke.
  • Further research is needed to clarify the role of temperature in stroke treatment.
Keywords:
MCA occlusionbody temperatureclot lysisischemic stroke

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