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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
What is the Immune System?01:38

What is the Immune System?

Overview
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 10, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

B Cell in Autoimmune Diseases.

Christiane S Hampe1

  • 1Department of Medicine, University of Washington, SLU-276, 850 Republican, Seattle, WA 98109, USA.

Scientifica
|June 29, 2013
PubMed
Summary
This summary is machine-generated.

B cells play a critical role in autoimmune diseases through various functions, influencing both antibody- and T cell-mediated conditions. This understanding is paving the way for novel B cell-targeted therapies.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Immunology
  • Autoimmunity
  • Cell Biology

Background:

  • B cells are key players in autoimmune diseases, exhibiting diverse functions beyond autoantibody production.
  • These functions include autoantigen presentation, T cell interaction, cytokine secretion, and ectopic germinal center formation.
  • B cell involvement extends to both antibody-mediated and T cell-mediated autoimmune conditions.

Purpose of the Study:

  • To provide an overview of B cell functions in autoimmunity.
  • To examine the specific roles of B cells in systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes.
  • To discuss current and novel B cell-based therapeutic strategies.

Main Methods:

  • Literature review and synthesis of existing research on B cells in autoimmunity.
  • Analysis of B cell involvement in specific autoimmune diseases.
  • Evaluation of current and emerging B cell-targeted therapies.

Main Results:

  • B cells contribute to autoimmunity through autoantibody secretion, antigen presentation, T cell interactions, cytokine release, and ectopic germinal center formation.
  • B cells are implicated in systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes.
  • Current therapies target B cells, with novel approaches focusing on selective pathogenic B cell targeting.

Conclusions:

  • The multifaceted roles of B cells in autoimmunity necessitate a comprehensive understanding for effective treatment.
  • Novel therapeutic strategies targeting specific B cell functions offer promising avenues for managing autoimmune diseases.
  • Selective targeting of pathogenic B cells represents a key future direction in autoimmune disease therapy.