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Related Experiment Video

Updated: May 10, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

HPV status after cold knife conization.

Goran Dimitrov1, Biljana Talevska, Sotir Nikolovski

  • 1University Clinic of Obstetrics & Gynecology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.

Akusherstvo I Ginekologiia
|July 2, 2013
PubMed
Summary

Human papillomavirus (HPV) DNA testing 8 months after cold knife conization predicts cervical intraepithelial neoplasia (CIN) persistence or recurrence. Positive HPV DNA results indicate a higher risk, guiding surveillance strategies for better patient management.

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Area of Science:

  • Gynecology
  • Oncology
  • Virology

Background:

  • Cervical intraepithelial neoplasia (CIN) management often involves cold knife conization.
  • Predicting CIN persistence or recurrence post-conization is crucial for patient outcomes.
  • The role of human papillomavirus (HPV) DNA testing in post-conization surveillance requires clarification.

Purpose of the Study:

  • To evaluate HPV DNA testing as a predictor of CIN persistence or recurrence after cold knife conization.
  • To determine if HPV DNA test results should influence surveillance protocols following cold knife excision.

Main Methods:

  • A retrospective study included 217 patients who underwent cold knife conization for CIN or microinvasive cervical cancer.
  • Follow-up HPV DNA testing was conducted 8 months post-conization.

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

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Last Updated: May 10, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

  • Patients were monitored every 4 months up to 24 months postoperatively.

    • Main Results:

    • Of 217 patients, 44 tested HPV DNA positive and 199 tested negative at 8 months.
    • Recurrent abnormalities were observed in 26 of 44 HPV DNA positive patients and 12 of 199 HPV DNA negative patients.
    • A positive HPV DNA test was identified as a significant risk factor for persistent or recurrent CIN.

    Conclusions:

    • HPV DNA testing 8 months post-conization is a valuable tool for predicting CIN persistence or recurrence.
    • HPV DNA test results can inform individualized patient management strategies.
    • HPV DNA negative patients require routine surveillance, while HPV DNA positive patients necessitate frequent and meticulous monitoring.