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Updated: May 10, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[Renal functional state in patients with myocardial infarction]
Insights
Kidney dysfunction is common in myocardial infarction (MI) patients, linked to age and comorbidities. Early detection of renal filtration function aids treatment and improves outcomes.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Context:
- Myocardial infarction (MI) is a leading cause of mortality.
- Renal dysfunction is increasingly recognized as a significant comorbidity in cardiovascular disease.
- Understanding the interplay between MI and kidney function is crucial for patient management.
Purpose:
- To investigate the prevalence and characteristics of renal dysfunction in patients with acute myocardial infarction.
- To identify factors associated with worsening kidney function in MI patients.
- To assess the clinical implications of renal dysfunction in the context of MI.
Summary:
- Retrospective analysis of 670 acute coronary syndrome cases (369 male, 292 female, age 33-85) revealed moderate to severe kidney dysfunction in most patients.
- Worsening renal function correlated with older age, fewer males, and comorbidities like hypertension, heart failure, prior MI, and diabetes mellitus.
- Glomerular filtration rate (GFR) was estimated using the MDRD formula and patients were grouped based on GFR levels.
Impact:
- Kidney dysfunction plays a critical role in the development of multiple comorbidities in MI patients.
- Implementing GFR calculation in routine practice can help identify renal filtration issues promptly.
- Timely identification and treatment adjustments can potentially reduce adverse outcomes in MI patients with renal dysfunction.
Aim:
To study renal dysfunction in patients with myocardial infarction (MI).
Subjects And Methods:
670 case histories of patients diagnosed with acute coronary syndrome, including 369 (55.8%) men and 292 (44.2%) women at the age of 33 to 85 years (mean age 64.8 +/- 11.7 years), were retrospectively studied. The authors considered comorbidities and analyzed complaints, history data, and the results of physical examinations, biochemical blood tests for plasma glucose, troponin, MB fractions of creatine phosphokinase and creatinine, and cholesterol in all the patients. Instrumental studies involved electro- and echocardiography. Glomerular filtration rate (GFR) was estimated using the MDRD formula. The patients were divided into groups according to GFR values: 1) > 90 ml/min/1.73 m2; 2) 60 to 89 ml/min/1.73 m2; 3) 30 to 59 ml/min/1.73 m2; 4) less than 30 ml/min/1.73 m2.
Results:
Most patients were found to have a moderate or significant reduction in kidney function. Worsening renal function in patients with MI was associated with advanced patient age, the lower proportion of men in the patient structure, the higher prevalence of concomitant cardiovascular diseases, such as arterial hypertension, chronic heart failure, and prior MI, and diabetes mellitus.
Conclusion:
The findings suggest that kidney dysfunction is of essential value in developing the multiplicity of comorbidities in patients with MI. The wide introduction of a GFR calculating method in daily medical practice will be able to adequately and timely identify renal filtration function and to make a correction into a treatment regimen, thus decreasing the number of poor outcomes.
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