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Updated: Jan 6, 2026

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
Published on: January 7, 2019
Antiparkinsonian Activity of Benzenesulfonamide Derivatives, Selective MAO-B Inhibitors
A L Khokhlov1, V N Fedorov1, A A Shetnev2
1Yaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
Abstract:
The anti-parkinsonian activity of benzolsulfonamide selective MAO-B inhibitors was evaluated in a model of experimental parkinsonism in white mice (systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP). Six candidate compounds (laboratory codes S6-S8 and S11-S13) were analyzed. Rasagiline was used as the reference drug. Only compound S13 was comparable to rasagiline in preventing the development of rigidity and hypokinesia in animals and surpassed the reference drug in correcting emotional and behavioral activity.
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