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Updated: May 10, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Metabolomics in neonatal life.

Vassilios Fanos1, Nicoletta Iacovidou, Melania Puddu

  • 1Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Italy. vafanos@tiscali.it

Early Human Development
|July 2, 2013
PubMed
Summary

Metabolomics, the study of metabolites, offers predictive insights into health. This review highlights its emerging clinical applications in neonatology, focusing on newborns and experimental models.

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Area of Science:

  • Biochemistry
  • Genomics
  • Neonatal Medicine

Background:

  • Metabolomics (metabonomics) systematically studies the complete set of metabolites in biological samples.
  • It is considered a highly innovative 'omics' science, offering predictive phenotypic insights.
  • The metabolome is increasingly viewed as 'new clinical biochemistry', integrating epigenetic factors.

Purpose of the Study:

  • To review the clinical applications of metabolomics in neonatology.
  • To present findings from recent experimental and newborn studies.
  • To highlight the potential of metabolomics in neonatal care.

Main Methods:

  • Literature review of metabolomics studies.
  • Analysis of experimental models in neonatology.
  • Examination of studies involving newborn metabolomic data.

Main Results:

  • Limited research exists on metabolomics in neonatal life (less than 60 papers in 3 years).
  • Recent studies show promise in experimental models and direct newborn applications.
  • Metabolomics provides a predictive phenotype, considering epigenetic variations.

Conclusions:

  • Metabolomics has significant potential for clinical applications in neonatology.
  • Further research is needed to fully integrate metabolomics into neonatal care.
  • This review consolidates current knowledge and future directions for neonatal metabolomics.