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Related Experiment Video

Updated: May 10, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Vitamin D, vitamin D binding protein, lung function and structure in COPD.

Isaac Berg¹, Corrine Hanson, Harlan Sayles

¹Division of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5300, United States.

Respiratory Medicine

|July 2, 2013

Summary

This pilot study found that vitamin D levels correlate with emphysema severity and lung function (FEV1) in COPD patients. It also suggests a link between vitamin D and exercise capacity, highlighting its potential role in COPD management.

Keywords:

25(OH)D Emphysema FEV1 Free vitamin D

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Last Updated: May 10, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

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Published on: February 2, 2024

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

Area of Science:

Pulmonary Medicine
Nutritional Science
Radiology

Background:

Vitamin D and vitamin D binding protein (DBP) are linked to Chronic Obstructive Pulmonary Disease (COPD) and FEV1.
Limited data exists on the relationship between emphysema, vitamin D, and DBP.

Purpose of the Study:

To investigate the association between vitamin D status, DBP, FEV1, and emphysema in COPD patients.
To explore vitamin D and DBP relationships with lung function and CT-defined emphysema.

Main Methods:

Serum 25(OH)D and DBP levels were measured in 498 COPD patients from the ECLIPSE study.
Subjects included smoker controls, non-smoker controls, and GOLD stages 2-4 with high/low emphysema burden.
Associations between vitamin D, DBP, FEV1, emphysema, and clinical data were analyzed.

Main Results:

Serum 25(OH)D correlated with FEV1 and emphysema severity.
25(OH)D was associated with six-minute walk distance and bronchodilator response.
DBP was associated with bone attenuation in emphysema patients, but not FEV1 or emphysema itself.

Conclusions:

This study provides the first evidence of a relationship between emphysema and vitamin D.
Further supports the link between vitamin D status and FEV1 in COPD patients.