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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Published on: April 2, 2012

Herpes zoster.

Kim M O'Connor1, Douglas S Paauw

  • 1Division of General Internal Medicine, University of Washington School of Medicine, WA, USA. koconnor@u.washington.edu

The Medical Clinics of North America
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Herpes zoster (shingles) affects quality of life, especially in older adults. Vaccination significantly reduces shingles incidence and its painful complication, post-herpetic neuralgia.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Public Health

Background:

  • Herpes zoster (shingles) is a prevalent viral infection impacting health-related quality of life.
  • The condition disproportionately affects individuals over 60 and the immunocompromised.
  • Post-herpetic neuralgia (PHN) is a common and debilitating complication, particularly in the elderly.

Purpose of the Study:

  • To summarize the epidemiology and impact of herpes zoster.
  • To highlight risk factors and complications, including post-herpetic neuralgia.
  • To emphasize the role of zoster vaccination in prevention.

Main Methods:

  • Literature review of herpes zoster epidemiology and clinical impact.
  • Analysis of risk factors for herpes zoster and post-herpetic neuralgia.
  • Evaluation of zoster vaccine efficacy in reducing disease incidence and complications.

Main Results:

  • Herpes zoster significantly diminishes health-related quality of life.
  • Immunosuppressed individuals and those over 60 are at higher risk.
  • Zoster vaccination is recommended for individuals over 60, reducing herpes zoster and PHN incidence.

Conclusions:

  • Herpes zoster poses a significant public health challenge, particularly for older adults.
  • Preventive strategies, such as vaccination, are crucial for mitigating the impact of herpes zoster and its complications.
  • Widespread vaccination can decrease the incidence of herpes zoster and post-herpetic neuralgia, improving patient outcomes.