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Vitamin D and muscle function: is there a threshold in the relation?

Hennie C J P Janssen¹, Marielle H Emmelot-Vonk, Harald J J Verhaar

¹Department of Geriatrics, University Medical Center Utrecht, Utrecht, The Netherlands. hcjp.janssen@gmail.com

Journal of the American Medical Directors Association

|July 2, 2013

Summary

Higher serum 25 hydroxyvitamin D (25OHD) levels correlate with better muscle mass, strength, and performance in adults. This association is strongest below 60 nmol/L, with no significant link above this vitamin D threshold.

Keywords:

Vitamin D elderly muscle function performance

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

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Published on: May 4, 2018

Area of Science:

Endocrinology
Gerontology
Sports Medicine

Background:

Serum 25-hydroxyvitamin D (25OHD) is crucial for bone health and has been linked to muscle function.
Understanding the relationship between vitamin D status and muscle health is important for aging populations.

Purpose of the Study:

To investigate the association between serum 25OHD concentration and muscle mass, strength, and performance.
To determine if a threshold exists for this association.

Main Methods:

Cross-sectional study of 802 independently living men and postmenopausal women (40-80 years) in the Netherlands.
Measurements included serum 25OHD, lean mass, handgrip strength, knee extension strength, and physical performance.
Adjustments were made for health-related and lifestyle factors.

Main Results:

Higher serum 25OHD levels were significantly associated with greater lean mass, handgrip strength, and physical performance.
These associations were most pronounced below a 25OHD level of 60 nmol/L.
Associations attenuated to null above the 60 nmol/L threshold, indicating a ceiling effect.

Conclusions:

In middle-aged and older adults, higher serum 25OHD is linked to better muscle mass, strength, and performance.
A vitamin D threshold of 60 nmol/L appears to exist for these benefits.
Maintaining adequate vitamin D levels may be important for preserving muscle health in aging individuals.