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Updated: May 10, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Structural synaptic plasticity in the hippocampus induced by spatial experience and its implications in information
M Carasatorre1, V Ramírez-Amaya1, S Díaz Cintra2
1Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México.
Introduction:
Long-lasting memory formation requires that groups of neurons processing new information develop the ability to reproduce the patterns of neural activity acquired by experience.
Development:
Changes in synaptic efficiency let neurons organise to form ensembles that repeat certain activity patterns again and again. Among other changes in synaptic plasticity, structural modifications tend to be long-lasting which suggests that they underlie long-term memory. There is a large body of evidence supporting that experience promotes changes in the synaptic structure, particularly in the hippocampus.
Conclusion:
Structural changes to the hippocampus may be functionally implicated in stabilising acquired memories and encoding new information.
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