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Related Concept Videos

Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

[Bone structure in rheumatoid arthritis].

Kumiko Ono1, Satoru Ohashi, Sakae Tanaka

  • 1Department of Orthopaedic Surgery, The University of Tokyo Hospital, Japan.

Clinical Calcium
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) triggers bone loss and fracture risk through joint inflammation and systemic factors. Understanding bone changes in RA is crucial for effective patient treatment and fracture prevention.

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Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
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Area of Science:

  • Rheumatology
  • Immunology
  • Orthopedics

Context:

  • Rheumatoid arthritis (RA) involves immune dysregulation and chronic inflammation.
  • This leads to activated osteoclast pathways, causing bone destruction around joints.
  • Systemic factors like reduced activity and steroid use contribute to osteoporosis in RA patients.

Purpose:

  • To highlight the mechanisms of bone loss in rheumatoid arthritis.
  • To emphasize the dual impact of local and systemic factors on bone health in RA.
  • To underscore the importance of assessing bone structure and fracture risk in RA management.

Summary:

  • RA activates osteoclasts via inflammation, leading to periarticular osteoporosis and local bone destruction.
  • Reduced physical activity and corticosteroid treatments exacerbate bone density loss and quality deterioration.
  • These effects collectively increase fracture risk in individuals with rheumatoid arthritis.

Impact:

  • Improved understanding of RA's skeletal complications.
  • Informed clinical decision-making for fracture risk assessment in RA patients.
  • Potential for targeted therapeutic strategies to preserve bone health in rheumatoid arthritis.