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Related Concept Videos

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Related Experiment Video

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

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Published on: August 8, 2014

Enhanced podoplanin expression in chronic maxillary sinusitis.

Jozef Zustin1, Hanna A Scheuer, Rainald Knecht

  • 1Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany. j.zustin@uke.uni-hamburg.de

In Vivo (Athens, Greece)
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Podoplanin is expressed in inflamed maxillary sinus lining, particularly in basal cells during chronic sinusitis. This suggests podoplanin

Keywords:
Chronic rhinosinusitisD2-40paranasal sinus mucosapodoplanin

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Area of Science:

  • Immunohistochemistry
  • Pathology
  • Otorhinolaryngology

Background:

  • Podoplanin expression is known in oral tissues and salivary glands.
  • It is associated with inflammatory and neoplastic conditions.
  • Its role in respiratory mucosa, especially maxillary sinus, is unclear.

Purpose of the Study:

  • To investigate podoplanin expression in inflamed maxillary sinus mucosa.
  • To determine if odontogenic sinusitis shows specific podoplanin patterns.
  • To explore podoplanin's role in chronic rhinosinusitis pathogenesis.

Main Methods:

  • Retrospective analysis of maxillary sinus biopsies (n=20).
  • Immunohistochemical staining using D2-40 antibody for podoplanin.
  • Comparison of expression in chronic rhinosinusitis with/without polyps, eosinophilic, and odontogenic sinusitis.

Main Results:

  • Podoplanin expression was detected in basal cells of inflamed maxillary sinus epithelium.
  • Enhanced expression was not observed in sinusitis with polyp formation.
  • Positivity was noted in the parabasal layer in sinusitis without polyps.
  • Podoplanin was present in non-neoplastic, inflamed sinus epithelium.

Conclusions:

  • Podoplanin is expressed in non-neoplastic, inflamed maxillary sinus mucosa.
  • The protein may play a role in chronic rhinosinusitis pathogenesis.
  • Podoplanin might be involved in inflammatory cell migration within the epithelium.