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Related Concept Videos

Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Meiosis I01:49

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Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
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Accessing the Cytotoxicity and Cell Response to Biomaterials
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Published on: July 8, 2021

Dentin dysplasia type I.

Aarti Singh1, Sangesh Gupta, Monal Bhaurao Yuwanati

  • 1Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

BMJ Case Reports
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Dentin dysplasia type I is a rare genetic disorder affecting dentin formation, leading to abnormal root development and pulp obliteration. This condition, seen in both primary and permanent teeth, requires careful diagnosis through clinical and radiographic examination.

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Area of Science:

  • Dentistry
  • Genetics
  • Oral Pathology

Background:

  • Dentin dysplasia type I (DD-I) is a rare hereditary dentin disorder.
  • It affects approximately 1 in 100,000 individuals.
  • DD-I presents with normal-appearing crowns but significant root and pulp abnormalities.

Observation:

  • Clinical presentation includes nearly normal teeth crowns and pronounced hypermobility.
  • Radiographic findings reveal obliterated pulp chambers and short, malformed roots.
  • Periapical radiolucencies are often present in non-carious teeth.

Findings:

  • The study details three cases exhibiting classic features of dentin dysplasia type I.
  • Confirmed diagnosis relies on characteristic radiographic and clinical manifestations.
  • DD-I impacts both primary and permanent dentitions.

Implications:

  • Accurate diagnosis of DD-I is crucial for appropriate dental management and treatment planning.
  • Understanding the radiographic hallmarks aids in differentiating DD-I from other dental anomalies.
  • Further research into the genetic basis and long-term prognosis of DD-I is warranted.