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Related Experiment Video

Updated: May 10, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Bleomycin-induced flagellate dermatitis.

Rachel Grynszpan¹, João Paulo Niemeyer-Corbellini, Marien Siqueira Soto Lopes

¹Sector of Dermatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

BMJ Case Reports

|July 2, 2013

Summary

This summary is machine-generated.

Flagellate dermatitis presents as characteristic linear skin lesions and is a known side effect of bleomycin, an anticancer drug. Prompt diagnosis and cessation of bleomycin are crucial for managing this condition in cancer patients.

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Area of Science:

Dermatology
Oncology
Pharmacology

Background:

Bleomycin is an established chemotherapeutic agent used in treating various cancers.
Flagellate dermatitis is a rare but distinct cutaneous adverse reaction associated with bleomycin therapy.
Early recognition is vital for timely intervention and management of this side effect.

Observation:

The patient, undergoing chemotherapy for Hodgkin's lymphoma, developed pruritic, erythematous lesions.
Lesions were distributed linearly on the lower limbs and back.
The clinical presentation was consistent with flagellate dermatitis.

Findings:

The observed skin lesions were diagnosed as flagellate dermatitis.
The condition was directly attributed to bleomycin treatment.
This highlights a specific side effect of bleomycin in a clinical setting.

Implications:

Physicians should maintain a high index of suspicion for flagellate dermatitis in patients receiving bleomycin.
Prompt identification allows for the interruption of bleomycin, potentially preventing disease progression or exacerbation.
Awareness of this adverse drug reaction is essential for optimizing cancer patient care and safety.