Related Experiment Video
Updated: May 10, 2026
07:13
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
Signet ring lymphoma: a potential diagnostic mishap.
1Section of Hematopathology, Department of Pathology, Baylor University Medical Center at Dallas.
Proceedings (Baylor University. Medical Center)
|July 2, 2013
Summary
Signet ring lymphomas feature malignant lymphoid cells with a distinctive "signet ring" look. Pathologists must differentiate these from adenocarcinoma using immunohistochemical stains or flow cytometry.
Area of Science:
- Pathology
- Hematology
- Oncology
Background:
- Signet ring lymphomas are rare lymphoid malignancies.
- Characterized by cytoplasmic inclusions displacing the nucleus, mimicking signet ring cells.
- Potential for misdiagnosis as adenocarcinoma exists.
Purpose of the Study:
- To highlight the diagnostic challenges of signet ring lymphomas.
- To emphasize the importance of immunohistochemistry and flow cytometry in differentiating these lymphomas.
- To increase pathologist awareness of this entity.
Main Methods:
- Review of pathological features of signet ring lymphomas.
- Comparison with adenocarcinoma morphology.
- Discussion of diagnostic modalities including immunohistochemical stains and flow cytometry.
Main Results:
- Signet ring cells, especially with vacuoles, can be confused with adenocarcinoma.
- Adequate tissue and appropriate studies are crucial for accurate diagnosis.
- Awareness of this entity aids in selecting correct diagnostic tests.
Conclusions:
- Accurate identification of signet ring lymphomas requires careful pathological assessment.
- Immunohistochemistry and flow cytometry are essential for distinguishing lymphomas from carcinomas.
- Pathologist vigilance is key to avoiding misdiagnosis and ensuring appropriate patient management.