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Updated: May 10, 2026
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
The potential for cell-based therapy in perinatal brain injuries
Andre W Phillips1, Michael V Johnston, Ali Fatemi
1The Hugo W. Moser Research Institute at Kennedy Krieger Institute Johns Hopkins University, Baltimore, Maryland, USA ; Department of Neurology Johns Hopkins University, Baltimore, Maryland, USA.
Insights
Stem cell therapy shows promise for preventing and reducing perinatal brain injuries, a major cause of cerebral palsy. Research highlights neuroprotective effects of cord blood and mesenchymal stem cells in neonatal hypoxia-ischemia.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Pediatrics
Background:
- Perinatal brain injuries are a significant global cause of cerebral palsy.
- Stem cell therapy is increasingly explored for its potential to mitigate these injuries.
Purpose of the Study:
- To review stem and progenitor cell types for therapeutic strategies in perinatal brain injuries.
- To summarize recent preclinical and clinical studies on stem cell therapy for these conditions.
Main Methods:
- Review of existing literature on stem cell types and their mechanisms.
- Analysis of preclinical animal studies and ongoing clinical trials.
Main Results:
- Cord blood and mesenchymal stem cells demonstrate neuroprotective effects in neonatal hypoxia-ischemia models.
- Identified mechanisms include immunomodulation, growth factor release, and anti-apoptotic effects.
Conclusions:
- Stem cell therapy offers a promising avenue for treating perinatal brain injuries.
- Further research and clinical studies are essential to establish efficacy and safety.
Abstract:
Perinatal brain injuries are a leading cause of cerebral palsy worldwide. The potential of stem cell therapy to prevent or reduce these impairments has been widely discussed within the medical and scientific communities and an increasing amount of research is being conducted in this field. Animal studies support the idea that a number of stem cells types, including cord blood and mesenchymal stem cells have a neuroprotective effect in neonatal hypoxia-ischemia. Both these cell types are readily available in a clinical setting. The mechanisms of action appear to be diverse, including immunomodulation, activation of endogenous stem cells, release of growth factors, and anti-apoptotic effects. Here, we review the different types of stem cells and progenitor cells that are potential candidates for therapeutic strategies in perinatal brain injuries, and summarize recent preclinical and clinical studies.
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