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Updated: May 10, 2026
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
The potential for cell-based therapy in perinatal brain injuries
Andre W Phillips1, Michael V Johnston, Ali Fatemi
1The Hugo W. Moser Research Institute at Kennedy Krieger Institute Johns Hopkins University, Baltimore, Maryland, USA ; Department of Neurology Johns Hopkins University, Baltimore, Maryland, USA.
Stem cell therapy shows promise for preventing and reducing perinatal brain injuries, a major cause of cerebral palsy. Research highlights neuroprotective effects of cord blood and mesenchymal stem cells in neonatal hypoxia-ischemia.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Pediatrics
Background:
- Perinatal brain injuries are a significant global cause of cerebral palsy.
- Stem cell therapy is increasingly explored for its potential to mitigate these injuries.
Purpose of the Study:
- To review stem and progenitor cell types for therapeutic strategies in perinatal brain injuries.
- To summarize recent preclinical and clinical studies on stem cell therapy for these conditions.
Main Methods:
- Review of existing literature on stem cell types and their mechanisms.
- Analysis of preclinical animal studies and ongoing clinical trials.
Main Results:
- Cord blood and mesenchymal stem cells demonstrate neuroprotective effects in neonatal hypoxia-ischemia models.
- Identified mechanisms include immunomodulation, growth factor release, and anti-apoptotic effects.
Conclusions:
- Stem cell therapy offers a promising avenue for treating perinatal brain injuries.
- Further research and clinical studies are essential to establish efficacy and safety.
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