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Evaluation of HS-CRP and Lipid Profile in COPD
Anup N Nillawar1, Kedar B Joshi, Sandip Bharat Patil
1Associate Professor, Department of Biochemistry, SBKS Medical College , Vadodara, Gujarat, India .
Insights
Chronic Obstructive Pulmonary Disease (COPD) is linked to cardiovascular disease (CVD). High-sensitivity C-reactive protein (HS-CRP) is a better CVD risk indicator in COPD patients than lipid profiles.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Biochemistry
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a significant public health issue, with cardiovascular events causing over 50% of patient mortality.
- Traditional cardiovascular disease (CVD) risk assessment relies on dyslipidemia, but high-sensitivity C-reactive protein (HS-CRP) is emerging as a novel marker.
- This study investigates HS-CRP and lipid indicators for CVD risk assessment in COPD patients.
Purpose of the Study:
- To evaluate the role of HS-CRP and lipid profiles in assessing cardiovascular disease (CVD) risk in patients with Chronic Obstructive Pulmonary Disease (COPD).
- To compare the efficacy of HS-CRP versus traditional lipid indicators in identifying CVD risk in COPD.
Main Methods:
- Forty-five diagnosed COPD patients and 45 matched healthy controls were enrolled.
- Fasting serum samples were analyzed for lipid profiles and HS-CRP levels.
- Kappa statistics were used to assess agreement between lipid parameters and HS-CRP for CVD risk estimation.
Main Results:
- No significant differences in lipid profiles were observed between COPD patients and controls.
- HS-CRP levels were significantly elevated in COPD patients compared to healthy controls.
- A poor agreement was found between lipid parameters and HS-CRP in estimating CVD risk, highlighting HS-CRP's independent importance.
Conclusions:
- COPD is a systemic inflammatory disease, as evidenced by elevated HS-CRP levels.
- Standard lipid profiles show no significant derangement in COPD patients, suggesting limited utility for CVD risk assessment.
- HS-CRP should be considered as an additional tool for cardiovascular risk assessment in COPD patients, warranting further prospective validation.
Introduction:
COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this study, we assessed the patients of COPD for CVD with HS-CRP and lipid indicators.
Material And Methods:
Forty Five diagnosed patients of COPD and 45 age, sex, and BMI matched healthy controls were enrolled for the study after the institutional ethical committee's clearance was obtained. The fasting serum samples of the study subjects were evaluated for the lipid profile and HS-CRP.
Results:
There was no statistical difference in the lipid profile in the two groups, while HS-CRP was significantly raised in the COPD patients. On applying kappa statistics, we found a poor agreement between the lipid parameters and HS-CRP in estimating the risk for CVD. This underlines the independent importance of HS-CRP in the CVD assessment of COPD patients.
Discussion:
GOLD has described COPD as a systemic chronic inflammatory disease which involves the lung and the distant organs by the emissary of the systemic inflammation, which is also an antecedent to cardiovascular diseases. COPD is a systemic inflammatory disease which is underlined by this study. But the derangement of the lipid indicators is not statistically significant. This suggests the addition of HS-CRP in the assessment of the COPD patients for CVD. This further needs to be ascertained in a large prospective model.
Conclusion:
COPD is systemic inflammatory disease, but there is hardly any derangement of the lipid indicators.
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