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Cardiovascular disease risk in schizophrenia patients: a case control study

Kedar B Joshi1, Anup Nillawar2, A P Thorat3

  • 1Assistant Professor, Department of Biochemistry GMC Aurangabad, Maharashtra, India .

Journal of Clinical and Diagnostic Research : JCDR
|February 20, 2014
PubMed

Insights

Schizophrenia patients exhibit elevated cardiovascular disease risk factors, including metabolic syndrome and dyslipidemia. Early monitoring for these cardiovascular disease risks is crucial for timely intervention in schizophrenia patients.

Area of Science:

  • Psychiatry and Cardiology
  • Clinical Research

Background:

  • Schizophrenia patients face increased risks of cardiovascular morbidity and mortality.
  • Understanding cardiovascular disease (CVD) risk in schizophrenia is critical.

Purpose of the Study:

  • To quantify CVD risk parameters in schizophrenia patients.
  • To compare CVD risk factors between schizophrenia patients and a healthy control group.

Main Methods:

  • A case-control study involving 45 schizophrenia patients and 41 healthy controls.
  • Measurement of body mass index, metabolic syndrome, lipid parameters, and high-sensitivity C-reactive protein (hs-CRP).
  • Assessment of metabolic syndrome and dyslipidemia based on NCEP ATP III guidelines.

Main Results:

  • Schizophrenia subjects had significantly higher waist circumference, triglycerides, and hs-CRP.
  • Lower HDL cholesterol levels were observed in schizophrenia patients.
  • Prevalence of metabolic syndrome (28.8%) and dyslipidemia (51.1%) was higher in the schizophrenia group.

Conclusions:

  • Schizophrenia patients have a heightened risk of cardiovascular events due to prevalent metabolic syndrome and dyslipidemia.
  • Regular monitoring of CVD risk factors is recommended for schizophrenia patients.
  • Timely physician referral for management of CVD risks in schizophrenia is essential.
Abstract

Keywords:
DyslipidemiaHS-CRPMetabolic Syndrome

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