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Updated: May 10, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

[Research advance in von Willebrand factor]

Xue-Mei Li1, Miao Jiang, Yi-Ming Zhao

  • 1Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Province, China. meijuan1989123@163.com

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 3, 2013
PubMed

von Willebrand factor (vWF) is a multimeric glycoprotein exclusively synthesized in endothelial cells and megakaryocytes. It plays important roles in the primary and secondary haemostasis. Deficiency or dysfunction of vWF may cause von Willebrand disease (vWD), and overexpression of vWF may cause thrombosis. Making an intensive study on vWF will help us to understand the pathophysiology, diagnosis and treatment of vWF-related diseases, such as vWD, TTP, venous thrombosis, stroke, and so on. In this article, the regulation of vWF activity and its relation with diseases mentioned above are reviewed.

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