Related Experiment Video
Updated: May 10, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Friction-induced pagetoid dyskeratosis
Faisal Al-Mohammedi1, Gillian C de Gannes, Richard I Crawford
1Department pf Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC.
Background:
Pagetoid dyskeratosis (PD) is characterized by pale cells within the epidermis resembling those of Paget disease. These cells have been seen as an incidental finding in a variety of benign papules most commonly located in intertriginous areas. The lesion is considered a reactive process in which a small proportion of the normal population of keratinocytes is altered. Among the triggers for this lesion, friction has been suggested; however, a direct cause-and-effect relationship has not yet been reported.
Results:
We confirmed the relationship between PD and friction in a biopsy taken from a 19-year-old woman who presented with clinical features indicating exogenously induced bullae and erosions and consented to a biopsy of a lesion immediately after its induction, demonstrating combined features of PD and friction bulla.
Related Concept Videos
Characteristics of Dry Friction
Before the wheelbarrow starts moving, the static frictional force acts tangentially to the contact surface, opposing the force that is about to induce the motion. This frictional force prevents the...
Degenerative Disc Disease ll: Pathophysiology
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Desmosomes
Peripheral Artery Disease I: Introduction
Diabetic Foot Ulcer
