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Related Experiment Video

Updated: May 10, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Prefrontal cortex activity during response selection predicts processing speed impairment in schizophrenia.

Neil D Woodward¹, Brittney Duffy, Haleh Karbasforoushan

¹Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA. neil.woodward@vanderbilt.edu

Journal of the International Neuropsychological Society : JINS

|July 3, 2013

Summary

Schizophrenia impairs response selection, impacting processing speed. Abnormal dorsolateral prefrontal cortex (PFC) activation during this process contributes to cognitive deficits, suggesting targeted interventions could help.

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Area of Science:

Neuroscience
Cognitive Psychology
Psychiatry

Background:

Processing speed is significantly impaired in schizophrenia, affecting functional outcomes.
Response selection, crucial for mapping stimuli to motor actions, is linked to processing speed deficits.

Purpose of the Study:

To investigate the relationship between behavioral and neural measures of response selection and processing speed in schizophrenia.
To identify the neural correlates of response selection deficits in schizophrenia.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to scan 26 patients with schizophrenia and 21 healthy controls during two- and four-choice reaction time (RT) tasks.
Participants completed the Wechsler Adult Intelligence Scale-III (WAIS) Processing Speed Index (PSI).

Main Results:

Response selection, measured by RT slowing between tasks, was impaired in schizophrenia and correlated with psychometric processing speed.
Schizophrenia patients showed greater dorsolateral prefrontal cortex (PFC) activation, which correlated with poorer WAIS PSI scores.

Conclusions:

Deficient response selection and abnormal dorsolateral PFC recruitment contribute to processing speed impairment in schizophrenia.
Interventions targeting response selection and dorsolateral PFC function may improve cognitive processing in schizophrenia.