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Related Concept Videos

Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Assessment of the Cardiovascular System II: Inspection01:29

Assessment of the Cardiovascular System II: Inspection

Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

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Abnormal findings observed during an inspection
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
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Layers of Connective Tissue Proper

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Management and predictors of ICU admission in DRESS: A multicentre retrospective cohort study.

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Related Experiment Video

Updated: May 10, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

DRESS syndrome.

Vincent Descamps1, Sylvie Ranger-Rogez2

  • 1Service de dermatologie, centre hospitalier Bichat Claude-Bernard, 46, rue Henri- Huchard, 75877 Paris, France.

Joint Bone Spine
|July 3, 2013
PubMed
Summary
This summary is machine-generated.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe drug reaction causing organ dysfunction. It involves genetic factors and human herpesvirus reactivation, leading to prolonged illness even after stopping the drug.

Keywords:
CytomegalovirusDIHSDRESSEpstein-Barr virusHLAHuman Herpesvirus 6HypersensitivityToxic dermatitis

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Area of Science:

  • Immunology
  • Pharmacology
  • Virology

Background:

  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe cutaneous adverse drug reaction.
  • It is increasingly recognized as a systemic condition with potential for life-threatening organ dysfunction.

Observation:

  • DRESS syndrome presents with a characteristic long latency period and prolonged course, often including flares post-drug withdrawal.
  • Clinical severity correlates with systemic manifestations, which can lead to multiorgan failure.

Findings:

  • Pathophysiology involves reactivation of human herpesviruses (HHVs), primarily HHV-6, driven by an aberrant immune response.
  • Genetic susceptibility factors and drug interactions with the major histocompatibility complex receptor contribute to T-cell mediated antiviral responses.

Implications:

  • Understanding DRESS pathophysiology is crucial for early diagnosis and management of this severe drug hypersensitivity.
  • Further research into immunogenetic factors and viral reactivation can guide therapeutic strategies and identify at-risk individuals.