Engineered nanostructured β-sheet peptides protect membrane proteins
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Updated: May 10, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
Houchao Tao1, Sung Chang Lee, Arne Moeller
1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Abstract:
We designed β-strand peptides that stabilize integral membrane proteins (IMPs). β-strand peptides self-assemble in solution as filaments and become restructured upon association with IMPs; resulting IMP-β-strand peptide complexes resisted aggregation when diluted in detergent-free buffer and were visible as stable, single particles with low detergent background in electron micrographs. β-strand peptides enabled clear visualization of flexible conformations in the highly dynamic ATP-binding cassette (ABC) transporter MsbA.
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