Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Chronological, Greulich-Pyle, and Modified Fels Skeletal Ages in Patients with Unilateral Infantile and Adolescent Blount Diseases.

JB & JS open access·2025
Same author

Analyzing Pelvic Asymmetry by Sex and Ancestry: Insights From an Osteological Collection.

Cureus·2024
Same author

The Modified Fels and Abbreviated Modified Fels Knee Skeletal-Maturity Systems in the Prediction of Leg-Length Discrepancy.

The Journal of bone and joint surgery. American volume·2023
Same author

Ipsilateral Healthy-segment Response to Leg Length Discrepancy.

Journal of pediatric orthopedics·2023
Same author

Clinical and Radiographic Assessment of Adult Function After Blount Disease in Childhood: An Exercise in Futility.

Journal of pediatric orthopedics·2023
Same author

Faster Rate of Correction with Distal Femoral Transphyseal Screws Versus Plates in Hemiepiphysiodesis for Coronal-Plane Knee Deformity: Age- and Sex-Matched Cohorts of Skeletally Immature Patients.

The Journal of bone and joint surgery. American volume·2023

Related Experiment Video

Updated: May 10, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

Blount disease.

John G Birch1

  • 1Texas Scottish Rite Hospital for Children, Dallas, TX, USA.

The Journal of the American Academy of Orthopaedic Surgeons
|July 3, 2013
PubMed
Summary
This summary is machine-generated.

Blount disease, a progressive tibial varus deformity in children, presents in infantile and adolescent forms. Early recognition is crucial for effective treatment and preventing complications like osteoarthritis.

More Related Videos

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Area of Science:

  • Orthopedics
  • Pediatric Orthopedics
  • Skeletal Dysplasias

Background:

  • Blount disease, also known as osteochondrosis deformans tibiae, is a progressive tibial varus deformity.
  • It affects children and adolescents, with recognized infantile and adolescent forms, and a potential juvenile type.
  • The exact etiology remains unknown, but childhood obesity is a significant associated factor.

Purpose of the Study:

  • To review the clinical and radiographic characteristics of Blount disease.
  • To discuss the potential complications if left untreated.
  • To highlight the importance of early diagnosis and appropriate management strategies.

Main Methods:

  • Review of existing literature on Blount disease.
  • Analysis of clinical presentations and radiographic findings.
  • Discussion of treatment outcomes based on disease classification.

Main Results:

  • Blount disease can lead to significant varus deformity, leg length discrepancies, and knee joint distortion.
  • Childhood obesity is strongly associated with Blount disease, complicating treatment.
  • Infantile Blount disease has variable progression, necessitating astute clinical assessment.

Conclusions:

  • Accurate diagnosis of Blount disease, particularly the infantile form, is essential for guiding treatment.
  • Effective management aims to correct deformity and prevent long-term sequelae such as osteoarthritis.
  • Understanding the interplay between obesity and Blount disease is critical for successful intervention.