Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of prior proton pump inhibitor use on gastric cancer survival: A population-based cohort study in the five Nordic countries.

The American journal of gastroenterology·2026
Same author

Peritonsillar abscess as a clinical sign of oropharyngeal cancer - a Swedish national cohort study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Patients' experiences of gastro-oesophageal reflux after oesophagectomy for cancer - a qualitative study.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same author

Response to Drs Zhe Zhang and Hongbo Wu.

Journal of the National Cancer Institute·2026
Same author

Achalasia and Risk of Esophageal Squamous Cell Carcinoma and Adenocarcinoma in a Multinational Study.

Gastroenterology·2026
Same author

Length of the proximal resection margin and survival after surgery for oesophageal cancer.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026

Related Experiment Video

Updated: May 10, 2026

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

Recent developments in esophageal adenocarcinoma.

Jesper Lagergren1, Pernilla Lagergren

  • 1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. jesper.lagergren@ki.se

CA: a Cancer Journal for Clinicians
|July 3, 2013
PubMed
Summary

Esophageal adenocarcinoma (EAC) is rising, particularly in men, with poor prognosis. Early detection and improved treatments offer hope, but effective prevention strategies are still needed.

Keywords:
Barrett esophagusesophagushealth-related quality of lifeincidenceneoplasmpatternsprognosistherapy

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Area of Science:

  • Gastroenterology and Oncology
  • Esophageal Cancer Research

Background:

  • Esophageal adenocarcinoma (EAC) presents with increasing incidence, male predominance, and poor prognosis.
  • Rising rates are linked to GERD, obesity, and declining H. pylori infection.
  • Current prevention is lacking, necessitating focus on early detection and improved therapies.

Purpose of the Study:

  • To review the key features of esophageal adenocarcinoma.
  • To discuss current understanding of its increasing incidence and risk factors.
  • To explore future directions in prevention, early detection, and treatment.

Main Methods:

  • Literature review and synthesis of current research on EAC.
  • Analysis of epidemiological trends and risk factors.
  • Evaluation of emerging diagnostic and therapeutic strategies.

Main Results:

  • EAC incidence is rising due to GERD, obesity, and reduced H. pylori.
  • Male predominance is notable but unexplained; hormonal factors may be involved.
  • No evidence-based preventive measures exist; focus is on high-risk screening (e.g., Barrett's esophagus) and improved surgical/oncologic care.

Conclusions:

  • Esophageal adenocarcinoma remains a challenging disease with poor prognosis despite some therapeutic advances.
  • Future efforts should concentrate on identifying high-risk groups for screening, refining surgical and oncologic treatments, and exploring novel preventive strategies.
  • Minimally invasive surgery and endoscopic therapies show promise for improving outcomes and quality of life.