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Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain

Published on: December 12, 2017

Neutrophil activation by Campylobacter concisus.

Nina B Sørensen¹, Hans L Nielsen, Kim Varming

¹Department of Infectious Diseases, Aalborg University Hospital, P O Box 365, DK9100 Aalborg, Denmark. henrik.nielsen@rn.dk.

|July 4, 2013

Summary

Campylobacter concisus activates neutrophils, crucial for inflammation. However, patient serum showed a weak IgG response, indicating limited systemic immunity against this emerging enteric pathogen.

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Published on: October 22, 2013

Area of Science:

Immunology
Microbiology
Infectious Diseases

Background:

Campylobacter concisus is an emerging enteric pathogen linked to prolonged diarrhea and inflammatory bowel disease.
Its interaction with the innate immune system and systemic immunoglobulin response during acute infection remain unclear.

Purpose of the Study:

To investigate the activation of neutrophils by C. concisus.
To assess the systemic immunoglobulin response in C. concisus infections.

Main Methods:

Neutrophils from healthy volunteers were activated with C. concisus isolates.
Neutrophil adherence molecule CD11b expression and oxidative burst response were measured.
Opsonic activity was assessed using heat-treated serum from patients and healthy controls.

Main Results:

All C. concisus isolates strongly activated neutrophils, increasing CD11b expression and oxidative burst.
Opsonization in heat-treated serum enhanced the chemiluminescence response.
Serum from C. concisus-infected patients showed no higher opsonic activity than control serum.

Conclusions:

C. concisus effectively activates innate immunity via neutrophils, crucial for acute inflammation.
The findings suggest a weak systemic IgG response to C. concisus infection.