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Updated: May 10, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

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Published on: October 13, 2021

Hollow microporous organic capsules.

Buyi Li¹, Xinjia Yang, Lingling Xia

¹School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road No. 1037, Wuhan 430074, China.

Scientific Reports

|July 4, 2013

Summary

Researchers developed hollow microporous organic capsules (HMOCs) for drug delivery and nanoscale reactions. These biocompatible, fluorescent HMOCs offer high drug loading and controlled release, showing promise for biomedical applications.

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Published on: May 16, 2022

Area of Science:

Materials Science
Nanotechnology
Polymer Chemistry

Background:

Hollow microporous organic capsules (HMOCs) combine the benefits of microporous polymers and nanocapsules.
Their unique morphology is advantageous for storage, reaction chambers, and controlled release systems.

Purpose of the Study:

To synthesize HMOCs with high surface area using facile emulsion polymerization and hypercrosslinking.
To evaluate their potential in drug delivery and as nanoscale reactors.

Main Methods:

Emulsion polymerization
Hypercrosslinking reactions
Drug loading and release studies
Nanoparticle synthesis using HMOCs as reactors

Main Results:

Successfully synthesized HMOCs with high surface area and tailored porous structures.
Achieved high drug loading efficiency and zero-order drug release kinetics.
Demonstrated the use of HMOCs as stabilizer-free nanoscale reactors for nanoparticle preparation.
Confirmed intrinsic biocompatibility and fluorescence of the HMOCs.

Conclusions:

HMOCs offer a versatile platform for drug delivery with controlled release profiles.
These capsules serve as effective nanoscale reactors for nanoparticle synthesis.
The biocompatibility and fluorescence of HMOCs highlight their potential in biomedical applications.