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Related Experiment Video

Updated: May 10, 2026

Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Tubulogenesis.

M Luisa Iruela-Arispe¹, Greg J Beitel

¹Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA. arispe@mcdb.ucla.edu

Development (Cambridge, England)

|July 4, 2013

Summary

This summary is machine-generated.

This review explores tubulogenesis, the process of biological tube formation in metazoans. It details the diverse molecular mechanisms and physical forces guiding cell shape changes to create essential transport tubes.

Keywords:

Endothelia Epithelia Lumen Morphogenesis Tubulogenesis

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Area of Science:

Developmental Biology
Cell Biology
Biophysics

Background:

Metazoans rely on epithelial and endothelial tubes for vital transport functions.
Biological tubes exhibit diverse formation mechanisms and regulatory pathways.
Understanding tubulogenesis is crucial for developmental and physiological processes.

Purpose of the Study:

To provide a comprehensive overview of tubulogenesis.
To elucidate the molecular processes driving tube formation.
To describe the physical forces involved in shaping biological tubes.

Main Methods:

Literature review of tubulogenesis research.
Synthesis of current understanding of molecular mechanisms.
Analysis of physical forces in tube development.

Main Results:

Multiple distinct mechanisms of tubulogenesis exist across metazoans.
Numerous regulatory events control cell shape changes during tube formation.
Specific molecular pathways and physical forces dictate tube dimensions.

Conclusions:

Tubulogenesis involves complex interplay of molecular signals and physical forces.
Diverse strategies are employed for forming essential biological tubes.
This review consolidates current knowledge on tubulogenesis mechanisms.