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Updated: May 10, 2026

13:04
A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
In vitro kinetic profiling of hepatitis C virus NS3 protease inhibitors by progress curve analysis
Rumin Zhang1, William T Windsor
1In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, NJ, USA.
Methods in Molecular Biology (Clifton, N.J.)
|July 4, 2013
Abstract:
Kinetic profiling of drug binding to its target reveals important mechanistic parameters including drug-target residence time. In this chapter, we focus on global progress curve analysis as a convenient method for kinetic profiling. Detailed guidelines with pros and cons for various experimental designs and data analysis are provided. Kinetic profiling of Boceprevir and Telaprevir is illustrated.

