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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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Related Experiment Video

Updated: May 10, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

[Osteoporosis in men].

E Biver1, B Uebelhart

  • 1Service des maladies osseuses, Departement des spécialités de medecine HUG, Geneve. emmanuel.biver@hcuge.ch

Revue Medicale Suisse
|July 5, 2013
PubMed
Summary
This summary is machine-generated.

Osteoporotic fractures affect 1 in 5 men by age 50. Key risk factors include prior fractures, glucocorticoid use, and androgen deprivation therapy, with treatments showing efficacy similar to women.

Related Experiment Videos

Last Updated: May 10, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Orthopedics

Context:

  • Osteoporosis significantly impacts men, with 20% experiencing fractures by age 50.
  • Risk factors extend beyond bone mineral density (BMD), including comorbidities and fall risk.
  • Common triggers for male osteoporosis include fragility fractures, long-term oral glucocorticoid use, and androgen deprivation therapy for prostate cancer.

Purpose:

  • To review the multifaceted nature of osteoporosis and fracture risk in men.
  • To highlight key risk factors and clinical situations associated with male osteoporosis.
  • To discuss the efficacy of osteoporosis treatments in men.

Summary:

  • Osteoporosis affects 1 in 5 men by age 50, with numerous risk factors beyond decreased bone mineral density (BMD).
  • Prevalent fragility fracture, oral glucocorticoid therapy (≥3 months), and androgen deprivation therapy are primary risk indicators.
  • Pharmacological interventions like bisphosphonates, denosumab, and teriparatide demonstrate efficacy in increasing BMD and altering bone turnover markers in men, comparable to women.
  • Zoledronic acid and denosumab have provided the initial anti-fracture data specifically for men.

Impact:

  • Enhances understanding of osteoporosis prevalence and risk stratification in the male population.
  • Informs clinical practice regarding the identification and management of high-risk men.
  • Supports the use of established osteoporosis therapies in men based on emerging evidence.