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Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

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Related Experiment Video

Updated: May 10, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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Published on: October 17, 2025

Automating bioanalytical sample analysis through enhanced system integration.

Vimal Patel1, Daniel Leach, Mark Hornberger

  • 1Amgen Inc., Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. vimalp@amgen.com

Bioanalysis
|July 5, 2013
PubMed
Summary
This summary is machine-generated.

Automating bioanalytical workflows using a laboratory information management system (LIMS) integrated with liquid handlers and microfluidics platforms improves efficiency. This integration streamlines sample processing and assay performance with minimal customization.

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Related Experiment Videos

Last Updated: May 10, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

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Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)
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Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Published on: December 18, 2020

Area of Science:

  • Bioanalytical Chemistry
  • Laboratory Automation
  • Assay Development

Background:

  • Manual processes in bioanalytical laboratories are labor-intensive and pose challenges to efficiency.
  • Automated liquid handlers offer solutions but face integration difficulties within existing laboratory workflows.
  • Upstream sample processing remains a bottleneck for high-throughput ligand binding assay (LBA) technologies.

Purpose of the Study:

  • To integrate a laboratory information management system (LIMS) with automated liquid handlers and microfluidics platforms.
  • To streamline sample analysis processes in a bioanalytical laboratory setting.
  • To demonstrate the feasibility of using off-the-shelf technologies for enhanced laboratory automation.

Main Methods:

  • Utilized three off-the-shelf technologies with minimal customization for sample analysis.
  • Extracted sample information from LIMS sequence files to guide automated liquid handler operations.
  • Employed a file conversion tool to prepare assay-ready plates for the microfluidics platform.
  • Tested the integrated system using a ligand binding assay (LBA) pharmacokinetic (PK) assay.

Main Results:

  • Successfully integrated LIMS with an automated liquid handler and microfluidics platform.
  • Demonstrated efficient sample processing and preparation for assay-ready plates.
  • The integrated system showed good sample dilution and assay performance in LBA PK assays.
  • The approach required minimal customization and resources from laboratory scientists.

Conclusions:

  • Achieved successful automation of sample analysis in bioanalytical laboratories through LIMS integration.
  • The use of readily available technologies with minor modifications minimizes resource requirements.
  • This integrated automation strategy holds potential for application with other analytical platforms.