Related Experiment Video
Updated: May 10, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
Published on: January 16, 2018
The cilium in lights: new views of an ancient organelle
1Nephrology Division, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Abstract:
Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How mammalian cilia function in vivo as mechanosensors, signal transducers, or in fluid propulsion has been difficult to study due to lack of tools for live imaging of cilia. A new transgenic mouse that enables tissue-specific GFP labeling of cilia creates new opportunities for using live imaging to understand cilium function and to better characterize the many genetic models of ciliopathies. See research article: http://www.ciliajournal.com/content/2/1/8.
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