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Updated: May 10, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Immune regulation in obesity-associated adipose inflammation
Jonathan M Han1, Megan K Levings
1Department of Surgery, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Abstract:
Adipose tissue inflammation is often a consequence of obesity and is characterized by infiltration and activation of immune cells that overproduce cytokines and chemokines. This apparent loss of immune regulation in obese adipose tissue contributes to the ongoing chronic inflammation that is thought to promote the degradation of metabolic parameters in obesity. Much recent work has sought to identify the immune cell subsets that are involved in adipose tissue inflammation, understand the mechanisms by which adipose tissue inflammation develops, and develop immunotherapeutic strategies to reverse this process. In this review, we describe the known mechanisms that underlie the loss of immune regulation in obesity-associated adipose tissue inflammation and set the stage for the development of novel therapeutic approaches.
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