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Published on: November 29, 2018
Matrix-producing metaplastic breast carcinoma - a rare malignancy.
Suresh J Bhosale1, Ashok Y Kshirsagar, Soniya R Sulhyan
1Department of Surgery, Anaesthesia and Pathology, Krishna Institute of Medical Sciences University (KIMSU), Karad, Maharashtra, India.
The American Journal of Case Reports
|July 5, 2013
Summary
Matrix-producing metaplastic breast carcinoma is a rare cancer. This case report details a 33-year-old female diagnosed and treated with surgery, highlighting its unique characteristics and better prognosis compared to other metaplastic carcinomas.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Metaplastic breast carcinomas are rare, comprising less than 1% of invasive breast cancers.
- These tumors exhibit metaplasia, transforming ductal carcinomas into non-glandular growth patterns.
Purpose of the Study:
- To present a case of matrix-producing metaplastic breast carcinoma in a young female patient.
- To discuss the diagnostic features, treatment, and prognostic implications of this rare entity.
Main Methods:
- A 33-year-old female presented with a palpable left breast lump.
- Fine-needle aspiration cytology (FNAC) confirmed malignancy.
- Modified radical mastectomy with axillary clearance was performed; histopathology and immunohistochemistry (keratin, EMA, S100) confirmed matrix-producing carcinoma.
Main Results:
- Histopathology revealed matrix-producing carcinoma with infiltrating duct carcinoma.
- Immunohistochemistry confirmed positivity for keratin, Epithelial Membrane Antigen (EMA), and S100.
- The patient recovered uneventfully following surgical treatment.
Conclusions:
- Matrix-producing breast carcinoma is a rare subtype of metaplastic carcinoma with cartilaginous or osseous differentiation.
- It demonstrates a better prognosis than other metaplastic carcinomas and is typically ER/PR-negative.
- Surgery (mastectomy or local excision) is the primary therapeutic approach.
