An efficient synthesis of the fully elaborated isoindolinone unit of muironolide A
Qing Xiao1, Kyle Young, Armen Zakarian
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
Organic Letters
|July 6, 2013
Abstract:
An efficient stereocontrolled construction of the fully substituted isoindolone subunit of muironolide A is described. The approach is centered on the intramolecular Diels-Alder reaction between the enol form of the β-keto amide and an α,β,γ,δ-unsaturated ester, followed by the installation of the cyclohexene double bond.
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