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Related Concept Videos

Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Tumor Progression

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The Parathyroid Glands00:59

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Related Experiment Video

Updated: May 10, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Clinicopathologic features of solid variant papillary thyroid cancer.

Hojin Chang1, Seok Mo Kim, Ki Won Chun

  • 1Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

ANZ Journal of Surgery
|July 6, 2013
PubMed
Summary

Solid variant papillary thyroid cancer (SVPTC) is rare, but this study suggests it may not be as aggressive as once believed. Clinical characteristics and outcomes for 14 SVPTC patients showed no recurrence or metastasis.

Keywords:
aggressivenesscancerpapillarysolidvariant

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Solid variant papillary thyroid cancer (SVPTC) is a rare thyroid malignancy with poorly defined clinical features.
  • Understanding SVPTC characteristics is crucial for diagnosis and treatment strategies.

Purpose of the Study:

  • To evaluate the clinical characteristics and outcomes of patients diagnosed with SVPTC.
  • To assess the diagnostic accuracy of preoperative fine needle aspiration cytology (FNAC) for SVPTC.

Main Methods:

  • Retrospective analysis of 14 patients with SVPTC diagnosed between 2008 and 2011.
  • Review of clinical data, preoperative ultrasound-guided FNAC, permanent pathology, and immunohistochemical staining.
  • Assessment of tumor size, margins, invasion, lymph node metastasis, and follow-up for recurrence and metastasis.

Main Results:

  • SVPTC represented 0.23% of papillary thyroid cancer (PTC) cases.
  • Preoperative FNAC misdiagnosed 78.6% of SVPTC cases as conventional PTC or suspected PTC.
  • Tumors were small (<2 cm), with infiltrative margins (57.1%) and extrathyroidal invasion (50.0%) observed in several cases. Lymph node metastases were present in 35.7% of patients.
  • No recurrence or distant metastasis was observed during a mean follow-up of 24 months.

Conclusions:

  • SVPTC may exhibit less aggressive behavior than previously assumed, despite potential for local invasion and metastasis.
  • Improved preoperative diagnostic methods are needed for SVPTC.
  • Further research with larger cohorts and longer follow-up is warranted to confirm these findings.