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Related Experiment Video

Updated: May 10, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Published on: February 23, 2024

Psoriasis as autoinflammatory disease.

Joaquin J Rivas Bejarano¹, Wendell C Valdecantos

¹Immunology, Global Medical Affairs, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA. bejarano.0214@yahoo.com

Dermatologic Clinics

|July 6, 2013

Summary

This summary is machine-generated.

Psoriasis is now viewed as a systemic inflammatory disease with autoinflammatory features, not just a skin condition. This shift highlights its genetic basis and links to other serious health issues.

Keywords:

Autoinflammatory disease Cytokines Genetics Immunopathogenesis Inflammasome Psoriasis TH cells TNF-α

Related Experiment Videos

Last Updated: May 10, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Published on: February 23, 2024

Area of Science:

Immunology
Dermatology
Genetics

Background:

Psoriasis was traditionally considered a localized autoimmune skin disease.
Emerging evidence suggests a broader systemic inflammatory component.
Autoinflammatory diseases share inflammatory pathways relevant to psoriasis.

Purpose of the Study:

To summarize evidence linking autoinflammatory diseases and psoriasis.
To re-evaluate the clinical and pathophysiologic nature of psoriasis.
To explore psoriasis as a systemic inflammatory condition.

Main Methods:

Review of existing evidence on autoinflammatory diseases and psoriasis.
Analysis of genetic factors contributing to psoriasis.
Discussion of cellular and molecular inflammatory networks.

Main Results:

Psoriasis exhibits significant genetically defined features.
A systemic inflammatory state is associated with psoriasis.
Psoriasis shares characteristics with autoinflammatory diseases.

Conclusions:

Psoriasis should be reclassified as a systemic inflammatory disease with autoinflammatory features.
This perspective shift impacts understanding of comorbidities.
Genetic and molecular networks are crucial in psoriasis pathogenesis.