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Published on: February 23, 2024
Psoriasis as autoinflammatory disease
Joaquin J Rivas Bejarano1, Wendell C Valdecantos
1Immunology, Global Medical Affairs, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA. bejarano.0214@yahoo.com
Abstract:
This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.
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