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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: May 10, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Autoinflammatory syndromes.

John J Cush1

  • 1Baylor Research Institute, Rheumatology Research, 9900 North Central Expressway, Suite 550, Dallas, TX 75231, USA. cushj@msn.com

Dermatologic Clinics
|July 6, 2013
PubMed
Summary

Autoinflammatory syndromes involve innate immune system dysregulation and inflammasome activation. This review covers common types, their features, skin manifestations, and diagnosis for periodic fevers.

Area of Science:

  • Immunology
  • Rheumatology
  • Genetics

Background:

  • Autoinflammatory syndromes are rare systemic inflammatory diseases.
  • They are characterized by innate immune system dysregulation and inflammasome activation.
  • Key features include recurrent fevers, rash, and organ inflammation.

Purpose of the Study:

  • To review common autoinflammatory syndromes.
  • To highlight their distinguishing clinical and dermatologic features.
  • To guide accurate diagnosis in patients with periodic febrile disorders.

Main Methods:

  • Literature review of common autoinflammatory syndromes.
  • Analysis of clinical presentations, including dermatologic manifestations.
  • Discussion of diagnostic approaches for intermittent febrile illnesses.
Keywords:
AutoinflammatoryCAPSPeriodic feverStill disease

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Main Results:

  • Common autoinflammatory syndromes share features of innate immune dysregulation and inflammasome activation.
  • Distinctive clinical and skin findings aid in differentiating these disorders.
  • Effective treatment often involves cytokine inhibitors.

Conclusions:

  • Accurate diagnosis of autoinflammatory syndromes is crucial for effective management.
  • Recognizing specific features can improve diagnostic accuracy.
  • Understanding these conditions is key for patients with recurrent fevers.