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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

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Updated: May 10, 2026

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

[Bone modeling and remodeling during osseointegration].

D Chappard1

  • 1LUNAM université, GEROM-LHEA groupe études remodelage osseux et biomatériaux, IRIS-IBS institut de biologie en santé, CHU d'Angers, Angers cedex, France. daniel.chappard@univ-angers.fr

Revue De Stomatologie, De Chirurgie Maxillo-Faciale Et De Chirurgie Orale
|July 6, 2013
PubMed
Summary
This summary is machine-generated.

Bone modeling by osteoblasts and bone remodeling by osteoblasts and osteoclasts are distinct processes. Direct bone modeling can occur with biomaterials, enhancing bone quality through lamellar bone deposition.

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The Establishment of a Murine Maxillary Orthodontic Model
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The Establishment of a Murine Maxillary Orthodontic Model

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The Establishment of a Murine Maxillary Orthodontic Model
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The Establishment of a Murine Maxillary Orthodontic Model

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Area of Science:

  • Cellular biology
  • Biomaterials science
  • Orthopedics

Context:

  • Bone development involves distinct cellular activities: modeling in embryos/fetuses and remodeling in mature skeletons.
  • Remodeling is a complex process involving osteoblasts and osteoclasts, crucial for mature bone maintenance.
  • Bone modeling, typically by osteoblasts alone, can be triggered by biomaterials like implants and grafts.

Purpose:

  • To review basic concepts of cell coupling in bone formation.
  • To explore the microscopic transition from bone modeling to remodeling, particularly with biomaterial contact.
  • To understand how biomaterials influence bone development and quality.

Summary:

  • Bone modeling, driven by osteoblasts, is key in embryonic skeletal development, while remodeling, involving both osteoblasts and osteoclasts, maintains mature bone.
  • Unlike remodeling, bone modeling can occur directly upon contact with biomaterials, such as dental implants.
  • This direct modeling enhances bone quality, forming superior lamellar bone compared to non-lamellar bone from modeling.

Impact:

  • Understanding cell coupling and the modeling-remodeling transition is vital for biomaterial design.
  • Biomaterial integration can leverage direct bone modeling to improve skeletal repair and implant osseointegration.
  • Enhanced bone quality through lamellar bone deposition offers superior biomechanical properties for implants and grafts.