Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biodegradable starch-based nanocomposite films with laser-synthesized silver nanoparticles: A materials approach for packaging.

International journal of biological macromolecules·2025

Same author

Effect of ozone application on bovine carcasses in abattoir cold chambers.

PloS one·2025

Same author

Variability in the acid adaptation of ten different O157:H7 and non-O157 Escherichia coli strains in orange juice and the impact on UV radiation resistance.

Food microbiology·2024

Same author

Vinasse: from a residue to a high added value biopolymer.

Bioresources and bioprocessing·2024

Same author

Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity.

Polymers·2023

Same author

Hybrid materials based on chitosan functionalized with green synthesized copper nanoparticles: Physico-chemical and antimicrobial analysis.

International journal of biological macromolecules·2023

Search research articles

Related Experiment Video

Updated: May 10, 2026

Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes

Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes

Published on: April 7, 2017

Potassium sorbate controlled release from corn starch films.

Olivia V López¹, Leda Giannuzzi, Noemí E Zaritzky

¹CIDCA (Centro de Investigación y Desarrollo en Criotecnología de Alimentos), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, 47 y 116S/N°, La Plata (B1900AJJ), Buenos Aires, Argentina. ovlopez75@yahoo.com.ar

Materials Science & Engineering. C, Materials for Biological Applications

|July 6, 2013

Summary

Active starch films incorporating potassium sorbate effectively inhibit microbial growth and extend cheese shelf life by 21%. These antimicrobial films offer a promising alternative to conventional food preservation methods.

Keywords:

Active corn starch films Antimicrobial capacity Controlled release Mathematical modeled Potassium sorbate

More Related Videos

Deposition of Porous Sorbents on Fabric Supports

Deposition of Porous Sorbents on Fabric Supports

Published on: June 12, 2018

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Related Experiment Videos

Last Updated: May 10, 2026

Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes

Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes

Published on: April 7, 2017

Deposition of Porous Sorbents on Fabric Supports

Deposition of Porous Sorbents on Fabric Supports

Published on: June 12, 2018

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

Area of Science:

Food Science
Material Science
Microbiology

Background:

Starch-based films are biodegradable and can be functionalized for active packaging.
Potassium sorbate is a common food preservative with antimicrobial properties.
Oxidative degradation of additives can limit the efficacy of active packaging.

Purpose of the Study:

To develop and characterize active starch films containing potassium sorbate.
To evaluate the antimicrobial efficacy and shelf-life extension capabilities of these films.
To investigate the release kinetics and degradation of potassium sorbate within the films.

Main Methods:

Active films were prepared by casting native and acetylated corn starch with glycerol and potassium sorbate.
Antimicrobial activity was tested against Candida spp., Penicillium spp., S. aureus, and Salmonella spp.
Film properties (color, transparency) and sorbate concentration were monitored during storage.
Shelf-life extension was assessed using refrigerated cheese.
Sorbate diffusion was modeled mathematically.

Main Results:

Active films showed increased yellowness and decreased transparency compared to control films.
The minimum inhibitory concentration of potassium sorbate was 0.3%.
Sorbate concentration decreased over time due to oxidative degradation.
Active films successfully inhibited the growth of tested microorganisms.
Active films extended the shelf life of refrigerated cheese by 21%.

Conclusions:

Active starch films with potassium sorbate are effective antimicrobial agents for food packaging.
These films demonstrate significant potential for extending the shelf life of perishable foods like cheese.
Further research into mitigating sorbate degradation could enhance the performance of these active packaging systems.