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Updated: May 10, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
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Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

CHD7 in charge of neurogenesis

Kimberly H Kim1, Charles W M Roberts

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Cell Stem Cell
|July 6, 2013
PubMed

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...