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Related Experiment Video

Updated: May 10, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

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Published on: January 7, 2019

Feline immunodeficiency virus latency.

Samantha J McDonnel1, Ellen E Sparger, Brian G Murphy

  • 1Department of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, 4206 Vet Med 3A, Davis, CA 95616, USA. sjmcdonnel@ucdavis.edu

Retrovirology
|July 9, 2013
PubMed
Summary

The feline immunodeficiency virus (FIV)-infected cat model offers a new avenue for studying lentiviral latency. This research explores FIV latency to advance potential HIV eradication strategies.

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Human Immunodeficiency Virus (HIV) persists in latent cellular reservoirs despite effective antiretroviral therapy.
  • Understanding lentiviral latency is crucial for developing a cure for HIV infection.
  • Animal models are essential for studying lentiviral latency mechanisms and therapeutic interventions.

Purpose of the Study:

  • To review the current understanding of Feline Immunodeficiency Virus (FIV) latency and chronic infection.
  • To compare FIV latency with that of other lentiviruses.
  • To establish the utility of the FIV-infected cat model for lentiviral eradication research.

Main Methods:

  • Literature review of studies on FIV latency and chronic infection.
  • Comparative analysis of FIV latency with other lentiviral models.
  • Assessment of the FIV-infected cat model's potential for latency research.

Main Results:

  • The FIV-infected cat model is a recent and less-characterized lentiviral latency model.
  • Several features make the FIV model attractive and potentially complementary to existing systems.
  • Existing data on FIV latency and chronic infection provide a foundation for its use.

Conclusions:

  • The FIV-infected cat model shows promise for advancing lentiviral latency research.
  • Further characterization of FIV latency is needed to fully leverage this model.
  • This model could contribute significantly to future research aimed at lentiviral eradication.