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Changes in the capillaries of the stria vascularis after hemorrhagic shock
K Watanabe1, K Yokoyama, H Harada
1Department of Otolaryngology, Tokyo Medical and Dental University, Japan.
Insights
Severe hemorrhagic shock blocked stria vascularis blood flow in guinea pigs. The spiral ligament remained unaffected, suggesting surrounding cells contribute to blood sludging in this inner ear region.
Area of Science:
- Oto-rhino-laryngology
- Physiology
- Microcirculation
Background:
- Hemorrhagic shock can significantly impact microcirculation.
- The stria vascularis and spiral ligament are critical structures within the inner ear responsible for endolymph production and maintenance.
Purpose of the Study:
- To investigate the effects of severe hemorrhagic shock on blood flow within the guinea pig inner ear.
- To determine if specific microvascular structures, such as the stria vascularis and spiral ligament, exhibit differential responses to shock.
Main Methods:
- Induction of severe hemorrhagic shock in guinea pigs.
- Microscopic examination of blood flow in the capillaries of the stria vascularis and spiral ligament.
Main Results:
- Complete blockage of blood flow was observed in the stria vascularis capillaries following hemorrhagic shock.
- Blood flow in the capillaries of the spiral ligament remained unaffected.
Conclusions:
- The stria vascularis microvasculature is highly susceptible to disruption during severe hemorrhagic shock.
- The unique cellular composition and arrangement surrounding the stria vascularis may predispose it to blood sludging under ischemic conditions.
Abstract:
As a result of severe hemorrhagic shock in guinea pigs, the blood flow in the capillaries of the stria vascularis was blocked, but that of the spiral ligament was unaffected. It is therefore postulated that the thick layer of basal cells and fibrocytes around the stria vascularis and the capillaries leaving the stria vascularis plays an important role in the formation of blood sludging.