Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantifying the administration and monitoring time burden of several disease-modifying therapies for relapsing multiple sclerosis in the United Kingdom: A time and motion study.

Multiple sclerosis and related disorders·2024

Same author

Network analysis characterizes key associations between subjective fatigue and specific depressive symptoms in early relapsing-remitting multiple sclerosis.

Multiple sclerosis and related disorders·2022

Same author

Stroke in central nervous system infections.

Annals of Indian Academy of Neurology·2022

Same author

A systematic review of European regional and national guidelines: a focus on the recommended use of nabiximols in the management of spasticity in multiple sclerosis.

Expert review of neurotherapeutics·2022

Same author

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

Brain communications·2021

Same author

The epidemiology of multiple sclerosis in the Scottish Highlands: Prevalence, incidence and time to confirmed diagnosis and treatment initiation.

Multiple sclerosis and related disorders·2020

Search research articles

Related Experiment Video

Updated: May 10, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

American trypanosomiasis.

Francisco Javier Carod-Artal¹

¹Neurology Department, Raigmore Hospital, Inverness, UK and Health Sciences and Medicine Faculty, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.

Handbook of Clinical Neurology

|July 9, 2013

Summary

Chagas disease, caused by Trypanosoma cruzi, affects millions globally. This parasitic infection can lead to severe heart and neurological conditions, with benznidazole and nifurtimox as primary treatments.

Keywords:

American trypanosomiasis Chagas disease Trypanosoma cruzi encephalitis stroke

More Related Videos

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Related Experiment Videos

Last Updated: May 10, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Area of Science:

Infectious Diseases
Parasitology
Tropical Medicine

Background:

American trypanosomiasis, or Chagas disease, is caused by the protozoan Trypanosoma cruzi.
It is endemic in Latin America, affecting 10-14 million people, and is emerging in Europe and the USA.
Transmission occurs via vectors (Reduviidae family), blood transfusions, congenital routes, and organ transplantation.

Purpose of the Study:

To provide a comprehensive overview of Chagas disease.
To highlight the transmission routes, clinical manifestations, and available treatments for Trypanosoma cruzi infection.

Main Methods:

Review of existing epidemiological and clinical literature on Chagas disease.
Summary of the life cycle and transmission dynamics of Trypanosoma cruzi.
Description of the pathological outcomes and therapeutic options.

Main Results:

Chagas disease presents acutely, often asymptomatic in childhood, but can progress to chronic stages.
Chronic Chagasic Cardiomyopathy involves heart failure, arrhythmias, and thromboembolism.
Neurological complications include encephalitis and chagomas; Chagas disease is a significant cause of ischemic stroke in Latin America.

Conclusions:

Chagas disease poses a substantial global health burden, necessitating increased awareness and control efforts.
Early diagnosis and treatment are crucial to prevent severe chronic complications.
Benznidazole and nifurtimox are the principal drugs for treating Trypanosoma cruzi infections.