Effects of geohelminth infections on neurological development

Published reviews vary on the question of whether geohelminth infections affect cognitive development: some claim that the scarcity of evidence means that it is unlikely that they do; others present modest evidence for an effect; and others raise the possibility that the damage is considerable but largely unresearched. This chapter reviews the characteristics of the geohelminths themselves and the pathways by which they could affect the development of children in endemic areas. It describes the progress made in the last decade in conceptualizing children's brains as complex adaptive systems, with the suggestion that infections at different stages in brain development might have different neurobehavioral consequences. An examination of research reports and review articles highlights the difficulties inherent in assessing the effects of geohelminth infections: other serious obstacles to healthy development in the same population may mask the effects of the geohelminths, and consequently the intensity and pathogenicity of the infection is probably an important issue. Selecting cognitive measures suitable for assessing development in very young children is no simple matter, and careful statistical analysis is required to tease out the primary and secondary factors at work. The insights gained from a broad range of relevant research reports have placed us in a better position to conduct more telling research into the effects of these widespread, but neglected, tropical diseases.